Univ. Prof. Institute of Pharmacy, University of Innsbruck, Austria Chief Scientific Officer, ThioMatrix GmbH, Austria.
Vice President - R&D, Sulphur Mills Limited., India
Associate Vice President, Ferring Controlled Therapeutics and External Technology, Scotland, UK
FRSC, FMASc, Alexander Von Humboldt Experienced Fellow. Professor, MAEER's Maharashtra Institute of Pharmacy, MIT Campus, Kothrud, Pune. Co-founder and Chief Scientific Officer, Actorius Innovations and Research (AIR), Pune, India.
Professor at Saarland University & Cofounder & Head, Department "Drug Delivery", Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany
Showalter Distinguished Professor of Biomedical Engineering, Purdue University, U.S.A.
Senior Lecturer and Director of the Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand
Group Leader Nanomedicines and Translational Drug Delivery group, Institute of Biomedical Engineering/Institute for Investigation and Innovation in Health (INEB/i3S) and Assistant Professor at IUCS/CESPU, University of Porto,Portugal
Lead Investigator, Biopharmaceutics Department, Biocon Bristol-Myers Squibb R&D Centre (BBRC), Syngene International Ltd., Bengaluru, India
Research Professor, Strathclyde Institute of Pharmacy & Biomedical Sciences, Glasgow, UK
Dr. Andreas Bernkop-Schnürch - Univ.-Prof. Institute of Pharmacy, University of Innsbruck, Austria Chief Scientific Officer, ThioMatrix GmbH, Austria
Since their introduction in the pharmaceutical arena thiolated polymers – designated thiomers - have attracted and inspired pharmaceutical scientists by their versatile properties. Due to the immobilization of thiol groups on well-established polymeric excipients such as alginate and chitosan various properties including mucoadhesive, in situ gelling, release controlling, permeation enhancing and efflux pump inhibiting properties are improved. The capability to form disulfide bonds within their structure, with mucus or tissues render them unique among biomaterials. These unique features of thiomers resulted in over ten clinical trials and numerous product developments so far. Due to their mucoadhesive properties thiomers can prolong the residence time of various types of drug delivery systems on mucosal membranes. As a consequence the local therapeutic effect of drugs can be prolonged. Thiolated alginate was used as coating material to enhance the mucoadhesive and drug release controlling properties for an intraoral metformin formulation for the management of periodontitis. Clinical studies on 20 subjects with this formulation indicated improvement of all clinical parameters post treatment. Furthermore, clinical studies focusing on the potential of polyacrylates to prolong the ocular residence time of a model drug showed a constant drug level in the lacrimal fluid over 8 hours with thiolated polyacrylic acid, whereas the corresponding non-thiolated polymer showed a rapid drug release and elimination already within the first hour. In another clinical trial mucoadhesive nanofibre mats with thiolated chitosan containing antimicrobial ingredients were shown to be higher mucoadhesive than the corresponding unmodified chitosan formulations. Furthermore, the potential of thiolated chitosan in treatment of dry eye syndrome was shown in various clinical trials. First product developments on thiolated chitosan such as Lacrimera® demonstrated that single-dose instillation for several days improves signs and symptoms in patients affected from dry eye disease from a variety of causes, who were refractory to standard treatment with lubricants. Thiolated hyaluronic acid was used as intraocular implant in patients with primary open angle glaucoma in a phase 1 study. As thiolated polymers exhibit biocompatibility, cellular mimicking properties and efficiently support proliferation and differentiation of various cell types, they are also used as scaffolds for tissue engineering. Furthermore thiolated polymers such as thiolated hyaluronic acid and thiolated chitosan were shown to exhibit wound healing properties. First products such as Hystem® (thiol-modified hyaluronan), Glycosil® (thiol-modified hyaluronan) and Gelin-S® (thiol-modified gelatin) have already entered the global market. All these clinical trials demonstrate the potential and safety of thiomers both as excipients for drug delivery and as active pharmaceutical ingredients. They are a helpful guidance for numerous further product developments based on thiomers.
Dr. Jayant Khandare, FRSC, FMASc, Alexander Von Humboldt Experienced Fellow. Professor, MAEER's Maharashtra Institute of Pharmacy, MIT Campus, Kothrud, Pune. Co-founder and Chief Scientific Officer, Actorius Innovations and Research (AIR), Pune, India.
The talk will highlight the ‘seed and soil theory’ of cancer metastasis, detection, and enumeration of circulating tumor cells (CTC) from cancer patients blood . The detection and enumeration of CTCs offer the utility with respect to prognosis in epithelial origin cancers, example, breast, colorectal, head and neck, and prostate cancers etc. The CTC analysis is highly implicated for the detection of early-stage metastasis with prognostics value, monitoring relapse, and in personalized cancer therapy. CTC monitoring is a non-invasive ‘real-time liquid biopsy’. Enumeration of CTCs sustain immense challenge in their capture due to low abundance in the peripheral blood (1 CTC per million other blood cells). CellSearch technology was clinically developed and approved by USFDA. This technology is an unmet need in India and is prohibitively expensive for many cancer patients especially for lower economic strata of society. The talk will detail ‘OncoDiscover’ platform consisting magneto-polymeric nanosystem. The talk will feature- CTC enumeration and imaging of cancer cells using clinical blood samples for monitoring disease progression. OncoDiscover, technology has been clinically validated with regulatory permissions in India. OncoDiscover ‘Liquid Biopsy Technology’ is set to be available with affordability for overall survival monitoring to cancer patients in India.
Dr. Claus – Michael Lehr Claus-Michael Lehr, Professor at Saarland University & Cofounder & Head, Department “Drug Delivery”, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany
The development of urgently needed novel anti-infectives is much limited by the difficult access to their site of action. While the receptors for most other drugs are located on the cell membrane and thus readily accessible for molecules from the blood plasma, anti-infective drugs often need to overcome some additional biological barriers.
In the context of pulmonary drug delivery, we recently succeed to establish the first human (hAELVi) and murin (mAELVi) alveolar epithelial lentivirus immortalized cell lines with AT-I like properies, which are now also commercially available.
Dr Ilva Rupenthal, Director at Large, CRS Inc., USA Senior Lecturer and Director of the Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand
While the eye is readily accessible from the outside of the body, it is a rather isolated organ with a number of barriers and elimination mechanisms in place to protect it from the environment, rendering efficient drug delivery to the ocular tissues difficult. Various pharmaceutical strategies, such as novel formulations and physical force-based techniques, have been investigated over the years to transport therapeutic agents effectively to both the anterior and the posterior segments of the eye.
This presentation will give an overview of the research performed within the Buchanan Ocular Therapeutics Unit including the investigation of novel therapeutics and innovative drug delivery systems for the management of dry eye, uveitis, diabetic retinopathy and age-related macular degeneration. Topics will include specific tissue targeting approaches using cell penetrating peptides and coated nanoparticles, the use of physical forces such as ultrasound to overcome the physiological barriers as well as a number of in vitro, ex vivo and in vivo models to adequately test such systems.
Dr. Ajay Saxena Lead Investigator, Biopharmaceutics Department, Biocon Bristol-Myers Squibb R&D Centre (BBRC), Syngene International Ltd., Bengaluru, India
Modified release formulations have been traditionally developed on the basis of targeted PK profile and deconvoluted in vitro drug release profile, overlooking the physiological hurdles faced by the product. Focus is shifting in utilizing an integrated in vitro (microdissolution), in silico (GastroPlus™ simulation) and in vivo (pre-clinical and clinical) approach to understand the underlining physiological challenges. This presentation will unveil Biopharmaceutics approach in providing a scientific rationale to design a modified release formulation targeting a robust clinical performance.
Dr. Hitesh Doshi, Vice President - R&D, Sulphur Mills Limited., India
The pharmaceutical industry has grown tremendously due to the research work on new drug delivery systems and their subsequent commercialization. The ease of availability of trained man power from pharmacy schools and well qualified academic staff has contributed greatly to the development of the pharmaceutical industry. Significant amount of research has been done in the field of veterinary drug delivery also.
However, the agrochemical formulation industry has lagged behind. Although there are several agricultural universities and colleges in India and abroad, there is no formal training given on developing agrochemical formulations. New product development and improvisations to existing products have been very slow. The opportunities of formulation research in the agrochemical space is immense. As a trained pharmacist one can easily use his experience in creating value added products for the agrochemical industry. The freedom to use several excipients further makes the development work all the more interesting and provides an opportunity to build intellectual property.
In the presentation, the speaker will talk about the existing agrochemical formulations, newer trends and novel drug delivery systems in the agrochemical space.
Dr. Janet Halliday - Key Note Speaker Associate Vice President, Ferring Controlled Therapeutics and External Technology, Scotland, United Kingdom
Drug delivery technologies are developed to improve treatments for patients. Technology innovation can spring from academic and commercial innovation. However good the science is, it is only of value for the business if it can be translated into successful products.
Ferring has successfully developed drug delivery science into products to Help Patients Live Healthy Lives in the fields of Women’s Health, Reproductive Medicine, Urology and Gastroenterology. Examples will be shared of polymer controlled release PROPESS® vaginal system, long acting topical TESTAVAN® gel and bowel cleanser CLENPIQ® solution.
Ferring and other organisations continue to work on bringing new technologies closer to the market in on-going clinical trials. The international rules for clinical study publication allows these novel technology approaches to be shared with the scientific community at large. Examples will be shared of prolonged vaginal delivery, sustained release injectables and orally administered peptide. This provides global awareness of where science does meet business needs.
Prof. Kinam Park – Key Note Speaker Prof of Pharmaceutics & Showalter Distinguished Prof of Biomedical Engineering, Purdue University & Founder & President Akina Inc., USA
The modern drug delivery technology is only 60 years old. During the first 30 years many breakthrough formulations were developed helping patients deal with various diseases effectively. The progress in the last few decades, however, has been slow, and many important drug delivery problems have not been resolved. The field has been overwhelmed by nanotechnology, nanomedicine, and many nano-sized drug delivery systems. The drug delivery field is at the strategic inflection point, and it is time for us to find new ways of developing effective drug delivery systems. The future of this field depends on nurturing talented young scientists with purpose, passion, and the conviction of doing meaningful science. The progress will be accelerated, if all of us achieve enlightened mindset embracing paradoxes and diverse ideas.
Prof. Bruno Sarmento Group Leader Nanomedicines and Translational Drug Delivery group, Institute of Biomedical Engineering/Institute for Investigation and Innovation in Health (INEB/i3S) and Assistant Professor at IUCS/CESPU, University of Porto, Portugal
In drug delivery field, bioavailability and specificity are key challenges in the establishment of advanced products. Nanoparticles have been proposed by our group as valid approaches to provide successful systems to deliver drugs to their site of action. Besides the proper control of nanoparticle matrix to provide a suitable release of drug payload, the surface of nanoparticles has a major impact on the interaction with biological barriers and cell membranes. We have studied thoroughly the interaction of nanoparticles with cells and mucus regarding their adhesive properties that modulates their mucoadhesive behaviour, ultimately related with passive targeting to mucosae. Understanding how nanosystems interact with individual mucin chains and the 3D structure of mucus is paramount, as a passive functionalization of nanoparticles may concern, exploring different biomaterials as mucus-modulators. Our active targeting approach for nanoparticles has been focused on ligand molecules attached to the surface of nanoparticles to increase the probability of binding to unregulated cell membrane receptors in key local effector sites. New and less - explored receptors are being targeted in engineered nanosystems, providing enhanced local and intracellular levels of drugs, without compromise the safety of the systems. In this talk, application of nanosystems for mucosal delivery of drugs with physiological and social impact, developed in our research group, will be presented. The surface modification of nanomaterials with targeting moieties, from biological biomacromolecules to biopolymers, has been successfully attained.
Clive G Wilson, Research Professor, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, Scotland, U.K.
Not too far back in our evolution, man was a nomadic hunter-gatherer and warrior, and food was distinctly unprocessed and fibre rich. The gut had to work hard to extract nutrients from a diverse matrix and protect the body against the occasional poisons from the seeds of berries and fruits which might be ingested. For many nutrients, absorption is an active process since the products of digestion are small and polar and the nature of the epithelium is a lipoidal barrier. In contrast, drugs have almost no nutritional value but are more easily absorbed passively. Mechanisms that help us to protect ourselves from poisons have evolved: specifically taste and the vomiting reflex have to be intentionally bypassed by disguise in a formulation. All the formulation work then has to be undone in the gut in a timely fashion to achieve the anticipated drug concentration -time exposure. Most drugs in the pipeline belong to Class to of the BCS or Class IIa or IIb of the DCS and therefore have limited aqueous solubility. This can limit the rate and extent of absorption, but is strongly influenced by formulation. Moving towards a robust in vitro test to predict performance is therefore a key step in the optimisation of an oral medicine. The task we face therefore is how to make continuous measurements in a murky media, whose composition changes along the gastrointestinal tract. Within the darkness of the gut, phenomena such as disintegration, super-saturation, precipitation and dissolution are occurring in unidentified segments. The simulated biological fluids that are used in pharmaceutical sciences are evolving recipes and much research is directed towards in silico prediction through better in vitro tests.
Our research programme within the OrBiTo program, in collaboration with other European universities and major pharmaceutical companies, has attempted to more closely define the influence of the composition of fluids in the gut in order to be able to improve the prediction of drug and formulation behaviour. This lecture will review some of the progress in this large initiative across the three feeder work packages.
We invite you to attend and participate in India’s largest gathering of drug delivery scientists!
A unique opportunity to meet and listen to the leading scientists of the world in person, to hear of the latest advances in the science of drug delivery from the inventors and innovators themselves and develop partnerships & collaborations!
Interact with energetic and enthusiastic young researchers and scholars who present their innovative ideas, often with unique protocols, for frugal product development!
|Platinum Sponsorship||Gold Sponsorship||Technology Showcase||Table Exhibit
|INR 5,00,000/-||INR 3,50,000/-||INR 2,00,000/-||Day1 INR 1,50,000/-
Day2 INR 1,00,000/-